Download The Role of Mechanically Induced ERK Phosphorylation in Stem Cell Adipogenesis complete Project Report.
The Role of Mechanically Induced ERK Phosphorylation in Stem Cell Adipogenesis complete Project Report – PDF Free Download
Abstract:
Mechanical cell stimulation has only recently been highlighted for its ability to direct cell function and fate. The development of techniques to apply controlled mechanical stimulation to cells has allowed researchers to examine the effects of forces on cell behavior. These studies have shown that cells, and in particular, stem cells are very sensitive to mechanical stimuli. While the potential impact of mechanical forces has been demonstrated by these studies, there have not been many studies that compare the differing effects of stimulation profiles and methods. Further, molecular mechanosensing mechanisms have not been identified. In this work, we compared the effects of cyclic tensile stretch and fluid flow induced shear on mesenchymal stem cell (MSC) adipogenesis. We also implicated extracellular signalregulated kinase (ERK) phosphorylation as a molecular mechanism involved in both cases.
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